Jurnal Sinaps

RADIKULOPATI LUMBAL

Muhammad Hafiz Moulvi — 2023-09-03

Low back pain is one of the neuromusculoskeletal complaint that is commonly found in practice. Low back pain usually happens in men above 40 yo, and women around 50-60 yo. The cause of low back pain varies, such as nerve root compression, trauma, bone degeneration, disc herniation, infection, inflammation, vascular disturbance, or can be neoplasm. Management of low back pain can be carried-out non-operatively or operatively, depending on the severity, the syumptoms that arise, and the response to non-operative treatment.

CANCER INDUCED BONE PAIN (CIBP)

Juwita — 2023-09-02

Cancer is characterized by the uncontrolled growth and spreading of abnormal cells. Cancer-induced bone pain (CIBP) is a significant problem affecting the majority of cancer patients, especially those suffering from metastatic disease due to cancer. The pathogenesis of CIBP involves tumor cells, bone cells, inflammatory microenvironment, and neural tissue. RNA noncoding miR-708-5p/CXCL13 has an important role in enhancement development of bone cancer pain through the initiation of neuroinflammation and hyperalgesia. Early recognition of bone pain in cancer and establishing a diagnosis are essential for timely intervention to relieve pain, prevent complications such as bone fractures, and improve the patient's quality of life. Management of bone pain in cancer patients is very complex and requires a multidisciplinary approach.

STROKE LARGE VESSEL OCCLUSION (LVO) SCREENING METHOD USING VISION, APHASIA, NEGLECT (VAN) ASSESSMENT

Andriyani — 2023-09-02

Acute stroke is a sudden episode of stroke that can cause long-term motor disturbances and impair cognitive abilities in patients. Stroke is the leading cause of the highest disability and the second leading cause of death worldwide. Approximately 62% of stroke patients are ischemic stroke, and 24-46% of all ischemic stroke cases involve large vessel occlusion (LVO). LVO stroke is a condition that occurs due to blockage in the large blood vessels in the brain and has a poor prognosis. The management of LVO stroke depends greatly on time to achieve satisfactory results in patients. The screening method considered effective in LVO stroke cases is using the Vision, Aphasia, Neglect (VAN) assessment based on the clinical symptoms of the patient. This VAN assessment tests the cortical function of patients while still making motor function as the main symptom. Patients in the Positive VAN category have a sensitivity of 100%, specificity of 90%, a positive predictive value of 74%, and a negative predictive value of 100% to detect LVO stroke.