CANCER INDUCED BONE PAIN (CIBP)

Authors

  • Juwita Bagian Biokimia, Fakultas Kedokteran Universitas Syiah Kuala, Banda Aceh
  • Hidayaturrahmi Bagian Anatomi Histologi, Fakultas Kedokteran Universitas Syiah Kuala, Banda Aceh
  • Ansari Adista Bagian Pendidikan Dokter, Fakultas Kedokteran Universitas Syiah Kuala, Banda Aceh
  • Khairunnisa Bagian Neurologi, Fakultas Kedokteran Universitas Syiah Kuala, Banda Aceh

Keywords:

: bone pain, cancer metastasis, CIBP pathophysiology, diagnose

Abstract

Cancer is characterized by the uncontrolled growth and spreading of abnormal cells. Cancer-induced bone pain (CIBP) is a significant problem affecting the majority of cancer patients, especially those suffering from metastatic disease due to cancer. The pathogenesis of CIBP involves tumor cells, bone cells, inflammatory microenvironment, and neural tissue. RNA noncoding miR-708-5p/CXCL13 has an important role in enhancement development of bone cancer pain through the initiation of neuroinflammation and hyperalgesia. Early recognition of bone pain in cancer and establishing a diagnosis are essential for timely intervention to relieve pain, prevent complications such as bone fractures, and improve the patient's quality of life. Management of bone pain in cancer patients is very complex and requires a multidisciplinary approach.

Published

2023-09-02

Issue

Vol. 6 No. 3 (2023): Volume 6 Nomor 3, September 2023

Section

Articles