DESCRIPTION OF COGNITIVE FUNCTION IN TYPE 2 DIABETES MELLITUS PATIENTS IN MANADO

GAMBARAN GANGGUAN FUNGSI KOGNITIF PADA PENDERITA DM TIPE 2 DI MANADO

Abstract

Background: Decreased cognitive function in patients with type 2 DM can have implications for adherence to medication management and regimens. Objective: to look for descriptions of cognitive impairment in patients with Type 2 diabetes. Methods: this study used a cross-sectional analytic observational study. Type 2 DM patients in Neurology and Endocrine-Metabolic clinic who met the inclusion criteria were examined for InaMOCA. Statistical analysis were performed using statistical software version 3.5.2. Results: A total of 70 samples were included in this study, 42 people (60%) had impaired cognitive function. The median score of InaMOCA 24 with the domain of cognitive function that was most disturbed was memory (91.43%) and language (75.71%). In the determinant, the variable Body Mass Index, Cholesterol and LDL have a relationship to cognitive function although it is still difficult to enforce at the univariate level because the OR value is close to 1. The albumin found in this study provides a protective effect on cognitive function disorders in patients with type 2 DM. Conclusion: 42 people (60%) had cognitive impairment with memory and language as the most disrupted domains. Albumin has a protective effect on cognitive impairment in this study.

Keywords: Impaired cognitive function, DM type 2, InaMOCA, Manado

ABSTRAK
Latar Belakang : DM Tipe 2 dapat menyebabkan gangguan kognitif. Penurunan fungsi kognitif pada penderita DM tipe 2 dapat berimplikasi kepada ketaatan penanganan dan rejimen obat-obatan. Tujuan : melihat gambaran gangguan kognitif pada penderita DM Tipe 2. Metode : penelitian ini menggunakan penelitian observasional analitik potong lintang. Pasien DM tipe 2 di poli Saraf dan poli Endokrin-Metabolik RS RDK yang memenuhi criteria inklusi dilakukan pemeriksaan InaMOCA. Analisis statistik dilakukan menggunakan perangkat lunak software statistic R versi 3.5.2. Hasil : Sebanyak 70 sampel dimasukkan dalam penelitian ini, 42 orang (60%) memiliki gangguan fungsi kognitif. Median skor InaMOCA 24 dengan domain fungsi kognitif yang paling banyak terganggu adalah memori (91,43%) dan bahasa (75,71%). Pada determinan, variable Indeks Massa Tubuh, Kolesterol dan LDL memiliki hubungan terhadap fungsi kognitif walaupun masih sulit ditegakkan pada level univariat karena nilai RO mendekati 1. Ditemukan albumin pada penelitian ini memberikan efek protektif terjadinya gangguan fungsi kognitif pada penderita DM tipe 2. Kesimpulan : sebanyak 42 orang (60%) memiliki gangguan fungsi kognitif dengan domain memori dan bahasa yang paling banyak terganggu. Albumin memberikan efek protektif terhandap gangguan fungsi kognitif pada penelitian ini.

Kata Kunci : Gangguan fungsi kognitif , DM tipe 2, InaMOCA, Manado