EXTRAPYRAMIDAL SYNDROME

Abstrak

Dopamine receptor blocking agents (DRBAs), better known as antipsychotics, are drugs widely used to treat psychotic disorders. This class of drugs could cause an adverse effect consist of akathisia, dystonia, parkinsonism, and tardive dyskinesia, which is known as extrapyramidal syndrome or EPS. The first-generation antipsychotics or typical antipsychotics cause a more severe form of EPS than the second-generation antipsychotics or atypical antipsychotics. EPS is a complication that should be recognized in anti-psychotic therapy. Efforts should also be done in order to reduce the risk of EPS and performing an optimal treatment in EPS cases. This manuscript focuses in discussing the patho-mechanism, clinical features, and treatment of EPS.

Keywords: extrapyramidal syndrome, anti-psychotic, patho-mechanism, clinical features, treatment.